New Study Co-authored by Prof. Jos Lelieveld Estimates Exposure to Air Pollution Increases COVID-19 Deaths by 15% Worldwide

Study co-authored by the Institute Prof. Jos Lelieveld estimates 15% of COVID-19 deaths worldwide could be attributed to air pollution. Long-term exposure to air pollution has been linked to an increased risk of dying from COVID-19 and, for the first time, a study has estimated the proportion of deaths from the coronavirus that could be attributable to particulate matter air pollution for every country in the world.

Professor Jos Lelieveld, Director at the Max Planck Institute for Chemistry in Mainz and Professor at Climate and Atmosphere Research Center (CARE-C) of The Cyprus Institute, stated: “Since the numbers of deaths from COVID-19 are increasing all the time, it’s not possible to give final numbers of COVID-19 deaths per country that could be attributed to air pollution. However, as an example, in the UK there have been more than 44,000 coronavirus deaths and we estimate that the fraction attributable to air pollution is 14%, meaning that about 6,000 deaths could have been avoided if the air were clean. In the USA, the 220,000 COVID deaths with a fraction of 18% yields more than 40,000 deaths attributable to air pollution”.

The study, published in the scientific journal Cardiovascular Research, estimated that about 15% of deaths worldwide from COVID-19 could be attributed to long-term exposure to air pollution. In Europe the proportion was about 19%, in North America it was 17%, and in East Asia 27%. In their paper, an international team of researchers write that these proportions are an estimate of “the fraction of COVID-19 deaths that could be avoided if the population were exposed to lower counterfactual air pollution levels without fossil fuel-related and other anthropogenic [caused by humans] emissions”.

Dr. Andrea Pozzer from the Max Planck Institute for Chemistry and first author of the study, stated that the attributable fraction does not however demonstrate a direct cause-effect relationship between air pollution and COVID-19 mortality. It is rather an indirect effect: “Our estimates show the importance of pollution on fatal health outcomes of the virus infection, i.e. by aggravating co-morbidities [other health conditions]”. Estimates show a very diverse picture for individual countries, for example, that anthropogenic air pollution contributed to 29% of coronavirus deaths in the Czech Republic, 27% in China, 26% in Germany. The proportion is lower for instance in Italy (15%) or Brazil (12%). Single figures are estimated for Israel (6%), Australia (3%) and New Zealand (1%). The study also presents the statistical confidence intervals of the calculations, being 5 to 33% worldwide. Dr. Andrea Pozzer, who is also affiliated to the International Centre for Theoretical Physics in Trieste in Italy, said: “Although our results have uncertainties, we can clearly distinguish the contribution of air pollution to COVID-19 mortality. Nevertheless, the actual mortality is influenced by many additional factors such as the country’s health system”.

Prof. Münzel explained the health effects of air pollution: “When people inhale polluted air, the very small polluting particles, the PM2.5, migrate from the lungs to the blood and blood vessels, causing inflammation and severe oxidative stress, which is an imbalance between free radicals and oxidants in the body that normally repair damage to cells”. This causes damage to the inner lining of arteries, the endothelium, and leads to the narrowing and stiffening of the arteries. The COVID-19 virus also enters the body via the lungs, causing similar damage to blood vessels, and it is now considered to be an endothelial disease. Prof. Münzel added: “If both long-term exposure to air pollution and infection with the COVID-19 virus come together then we have an additive adverse effect on health, particularly with respect to the heart and blood vessels, which leads to greater vulnerability and less resilience to COVID-19. If you already have a heart disease, then air pollution and coronavirus infection will aggravate disorders that can lead to heart attacks, heart failure and strokes. Particulate matter seems to increase the activity of a receptor on cell surfaces, called ACE-2, that is known to be involved in the way COVID-19 infects cells. Hence, we have a ‘double hit’: air pollution damages the lungs and increases the activity of ACE-2, which in turn leads to enhanced uptake of the virus by the lungs and probably by the blood vessels and the heart”.

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